ionis.com - Email Domain Verification & Deliverability Report

Active Corporate Email

Organization: Ionis Pharmaceuticals

Mail Server: Microsoft 365

Verified 3 days ago

Verify email addresses @ionis.com. View MX records, mail server configuration, and authentication status for Ionis Pharmaceuticals.

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MX Records for ionis.com

Priority	Mail Server	IP Address
0	ionis-com.mail.protection.outlook.com	`52.101.41.180`

SMTP Status: Responding

SMTP Banner:

220 DS1PEPF00017097.mail.protection.outlook.com Microsoft ESMTP MAIL Service ready at Mon, 9 Mar 2026 11:10:14 +0000 [08DE79E190387C33]

ionis.com uses Microsoft 365 mail servers, which means emails are processed through Microsoft 365 infrastructure with their built-in spam filtering and security controls.

Email Authentication for ionis.com

SPF Record Pass

v=spf1 include:spf.mailjet.com include:spf.protection.outlook.com include:_spf.salesforce.com ~all

Authorized Senders:

spf.mailjet.com spf.protection.outlook.com _spf.salesforce.com

SPF (Sender Policy Framework) specifies which mail servers are authorized to send email on behalf of ionis.com.

DMARC Record None

v=DMARC1; p=none; rua=mailto:eb22613323554803af9b30b9012c1599@dmarc-reports.cloudflare.net; ruf=mailto:dmarc@ionis.com

DMARC (Domain-based Message Authentication) tells receiving servers what to do with emails that fail authentication checks.

DKIM Found

DKIM signatures were detected for ionis.com, confirming that this domain cryptographically signs outgoing emails.

Authentication Summary: ionis.com has full email authentication configured with SPF, DMARC, and DKIM. This provides strong protection against email spoofing and phishing. Emails sent from this domain are well-authenticated and likely to have high deliverability.

WHOIS & Domain Information

Registration Details

Domain: ionis.com
TLD: .com
Created: 1999-12-30
Updated: 2025-04-03
Expires: 2034-12-30
Domain Age: 26 years

Registrar

Name: GoDaddy Corporate Domains, LLC
IANA ID: 3786

Registrant Contact

Name: Ionis IT
Organization: Ionis Pharmaceuticals, Inc.
Location: Carlsbad, CA, UNITED STATES

Technical Contact

Name: Ionis IT
Organization: Ionis Pharmaceuticals, Inc.
Location: Carlsbad, CA, UNITED STATES

Name Servers

HASSLO.NS.CLOUDFLARE.COM
KAYLEIGH.NS.CLOUDFLARE.COM

How to Verify ionis.com Email Addresses

Frequently Asked Questions

Is ionis.com a valid corporate email domain?

Yes, ionis.com is the official corporate email domain for Ionis Pharmaceuticals. It is used for internal business communications and is not available for public registration.

Is ionis.com a disposable or temporary email provider?

No, ionis.com is a corporate email domain belonging to Ionis Pharmaceuticals, used exclusively by employees and authorized personnel.

What mail server does ionis.com use?

ionis.com uses enterprise-grade mail infrastructure. Check the MX records section above for specific mail server details.

Can I send marketing emails to ionis.com addresses?

B2B marketing to ionis.com requires proper consent. Corporate domains may use catch-all configurations, so verify individual addresses before sending.

How do I verify an email address at ionis.com?

Corporate domains like ionis.com may use catch-all configurations. Use BulkEmailChecker's advanced verification to detect catch-all behavior.

How can I verify if an email address at ionis.com is valid?

The fastest and most accurate way to verify a ionis.com email address is to use BulkEmailChecker's free email verification tool. Simply enter the full email address and our system performs SMTP-level validation by connecting directly to ionis.com's mail servers. You'll get instant results showing whether the mailbox exists, is deliverable, and is safe to send to, all without sending a single email.

Can I check if a ionis.com email exists without sending an email?

Yes. BulkEmailChecker uses SMTP verification to check if a ionis.com mailbox exists without ever delivering an email. Our system connects to the domain's mail server, performs an SMTP handshake, and queries the mail server to confirm whether the recipient address is valid. This process is completely invisible to the email recipient and does not affect your sender reputation.

What happens if I send emails to invalid ionis.com addresses?

Sending to invalid email addresses causes hard bounces, which directly damage your sender reputation. Internet Service Providers (ISPs) and email providers track your bounce rate, and if it exceeds 2%, your emails may start landing in spam folders or get blocked entirely. Verifying ionis.com addresses with BulkEmailChecker before sending prevents bounces and keeps your deliverability high.

How do I verify a large list of ionis.com email addresses?

BulkEmailChecker's bulk verification service lets you upload a CSV or TXT file containing thousands of ionis.com email addresses and verify them all at once. Each address goes through 30+ verification checks including syntax validation, DNS/MX lookup, SMTP verification, disposable domain detection, and spam trap identification. Results are typically ready within minutes and can be downloaded as a clean, verified list.

What is email verification and why does it matter?

Email verification is the process of confirming that an email address is real, properly formatted, and capable of receiving messages. It matters because sending to invalid addresses causes bounces, damages your sender reputation, wastes marketing budget, and can get your sending IP blacklisted. BulkEmailChecker verifies addresses at the SMTP level, the most accurate method available, ensuring your emails reach real people.

What are MX records and how do they affect email delivery?

MX (Mail Exchange) records are DNS entries that specify which mail servers are responsible for receiving email for a domain. When you send an email, your mail server looks up the recipient domain's MX records to find where to deliver the message. If a domain has no MX records, it cannot receive email. BulkEmailChecker checks MX records as part of every verification to confirm the domain is configured for email delivery.

What is a catch-all domain and how does it affect verification?

A catch-all (or accept-all) domain is configured to accept email sent to any address at that domain, regardless of whether the specific mailbox exists. This makes it harder to verify individual addresses because the server always responds positively. BulkEmailChecker detects catch-all configurations and flags them in verification results so you can make informed decisions about sending to those addresses.

Can I integrate email verification into my website or application?

Yes. BulkEmailChecker offers a real-time email verification API that you can integrate into signup forms, CRM systems, lead capture tools, and any application that collects email addresses. The API validates addresses at the point of entry, blocking invalid, disposable, and risky emails before they enter your database. Integration takes just a single API call with response times under 3 seconds.

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